<i>BIRC5</i>, <i>GAJ5,</i> and lncRNA NPHP3-AS1 Are Correlated with the Development of Atrial Fibrillation-Valvular Heart Disease

The aim of this study was to explore the pivotal genes or lncRNAs involved in progression atrial fibrillation (AF) -valvular heart disease (VHD). mRNA profiling GSE113013 obtained from Gene Expression Omnibus database. identification differentially expressed (DEGs) and long non-coding RNAs (DElncRNAs) performed. Ontology Kyoto Encyclopedia Genes Genomes pathway enrichment analyses were carried out for DEGs. Then, construction protein-protein interaction (PPI) network conducted. An lncRNA-miRNA-target ceRNA constructed after obtaining microRNAs (miRNA) related DElncRNAs. Ultimately, key disease-related screened. A total 399 DEGs 145 DElncRNAs obtained. There 283 nodes 588 pairs PPI network, synaptosome-associated protein 25 (SNAP25) had higher degrees (degree = 22) network. 65 Here, Baculoviral IAP Repeat Containing 5 (BIRC5) regulated by hsa-miR-1285-3p, which lncRNA NPHP3-AS1. Gap Junction Protein Alpha (GAJ5) hsa-miR-4505, hsa-miR-1972, hsa-miR-1199-5p. In particular, GAJ5 enriched function ion transmembrane transport regulation, whereas BIRC5 apoptosis-multiple species pathway. Similarly, Potassium Inwardly Rectifying Channel Subfamily J Member 6 (KCNJ6) an channel complex. VENN analysis identified GJA5 as AF-related genes. KCNJ6, SNAP25, GJA5, BIRC5, NPHP3-AS1 likely be associated with AF-VHD development.